CEP170,中心体蛋白CEP170抗体

产品编号HZ-13852R
英文名称CEP170
中文名称中心体蛋白CEP170抗体
别 名XRCC5 binding protein; 4933426L22Rik; A330004A13Rik; AI195353; Centrosomal protein 170kDa; Cep170; FAM68A; KAB; KARP 1 binding protein; KARP1 binding protein; KIAA0470.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
CEP170,中心体蛋白CEP170抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量175kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CEP170
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CEP170,中心体蛋白CEP170抗体PubMedPubMed
产品介绍background:
The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

Function:
CEP170, centrosomal protein 170kDa, plays a role in microtubule organization. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes.

Subcellular Location:
Centrosome, centriole. Cytoplasm, cytoskeleton. Associated with the mature mother centriole. Associated with spindle microtubules during mitosis.

Post-translational modifications:
Phosphorylated; probably by PLK1.

Similarity:
Belongs to the CEP170 family.
Contains 1 FHA domain.

Gene ID:
9859

Database links:
Entrez Gene: 9859 Human
SwissProt: Q5SW79 Human

CEP170,中心体蛋白CEP170抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.